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Product Description

 

 

Indications

Listed in Dosage.
DosageAdult: IV Increase yield of autologous blood As epoetin alfa or zeta: 600 u/kg twice wkly for 3 wk before surgery.IV/SC Anaemia of chronic renal failure As epoetin alfa: Predialysis and haemodialysis: Initial: 50 u/kg 3 times/wk; Peritoneal dialysis: 50 u/kg twice wkly. Anaemia in zidovudine-treated HIV-infected patients As epoetin alfa: Initial: 100 u/kg 3 times/wk for 8 wk. Max: 300 u/kg 3 times/wk. SC Anaemia related to non-myeloid malignant disease chemotherapy As epoetin alfa or zeta: Initial: 150 iu/kg 3 times/wk, up to 300 iu/kg 3 times/wk.
Click to view erythropoietin Dosage by Indications
ContraindicationsUncontrolled hypertension, hypersensitivity to mammalian cell products and human albumin.
Special PrecautionsChronic renal failure, ischaemic heart diseases, hypertension, pregnancy, seizures, liver dysfunction, lactation.
Adverse Drug ReactionsHypertension, myalgia, arthralgia, flu-like syndrome, rashes and urticaria.
Potentially Fatal: Hypertensive crisis with encephalopathy-like symptoms e.g. headache, confusion, generalised seizures. Thrombosis.
Drug InteractionsHaematinics enhance efficiency. Increased dose of heparin in patients undergoing dialysis.
Click to view more erythropoietin Drug Interactions
Pregnancy Category (US FDA)
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Mechanism of ActionFor details of the mechanism of action, pharmacology and pharmacokinetics and toxicology ... click to view erythropoietin
CIMS ClassHaematopoietic Agents
ATC ClassificationB03XA01 - erythropoietin ; Belongs to the class of other antianemic preparations.

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